Letrozole is a medication primarily prescribed for the treatment of early breast cancer in women who have experienced menopause. It is particularly effective for those who have undergone other treatments, such as radiation or surgery, and for patients who have already been treated with tamoxifen for five years. Additionally, letrozole is utilized in cases where breast cancer has spread within the breast or to other areas of the body, or when the disease has worsened during tamoxifen treatment.
Mechanism of Action
Letrozole belongs to a class of medications known as nonsteroidal aromatase inhibitors. Its primary function is to decrease the amount of estrogen produced by the body. Since some types of breast cancer cells require estrogen to grow, reducing estrogen levels can slow down or halt the growth of these cancer cells.
Administration Guidelines
Letrozole is administered orally in tablet form, typically taken once a day with or without food. It is crucial for patients to take letrozole at approximately the same time each day and adhere strictly to their prescription instructions. Patients may need to continue taking letrozole for several years, even if they feel well, and should not discontinue use without consulting their healthcare provider.
Precautions and Contraindications
Before starting letrozole, patients should inform their doctor about any allergies to medications or ingredients in letrozole tablets. It is also important to disclose any other medications being taken, including over-the-counter drugs and supplements. Women who are pregnant or breastfeeding should avoid this medication due to potential harm to the fetus or infant.
Potential Side Effects
Common side effects associated with letrozole include hot flashes, night sweats, nausea, vomiting, loss of appetite, constipation, diarrhea, heartburn, stomach pain, fatigue, headaches, dizziness, weakness, joint pain, hair loss, and changes in weight. Serious side effects may include chest pain, rash or hives, difficulty breathing, unusual bleeding or bruising, liver issues (e.g., yellowing skin), flu-like symptoms, and signs of blood clots.
Monitoring and Follow-Up Care
Patients on letrozole should maintain regular appointments with their healthcare providers for monitoring purposes. This includes lab tests to assess how well the body is responding to treatment and checking for any adverse effects.
Storage and Disposal Instructions
Letrozole should be stored at room temperature in its original container and kept out of reach of children. Unused medications should not be flushed down the toilet but rather disposed of through designated medicine take-back programs.
In summary:
- Letrozoleis used primarily for treating early breast cancer in postmenopausal women.
- It works by inhibiting estrogen production.
- Administered orally once daily.
- Requires careful monitoring due to potential side effects.
- Proper storage and disposal are essential.
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