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Nolvadex 20Mg
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Nolvadex 20Mg

$78.00

NOLVADEX, known generically as tamoxifen citrate, is a selective estrogen receptor modulator (SERM) primarily used in the treatment and prevention of breast cancer. It is effective for both early and advanced estrogen receptor-positive breast cancer in women and men. Tamoxifen works by binding to estrogen receptors, thereby inhibiting the growth of estrogen-dependent tumors.

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NOLVADEX (Tamoxifen Citrate)

Overview NOLVADEX, known generically as tamoxifen citrate, is a selective estrogen receptor modulator (SERM) primarily used in the treatment and prevention of breast cancer. It is effective for both early and advanced estrogen receptor-positive breast cancer in women and men. Tamoxifen works by binding to estrogen receptors, thereby inhibiting the growth of estrogen-dependent tumors.

Indications NOLVADEX is indicated for:

  • Metastatic Breast Cancer:Treatment in both premenopausal and postmenopausal women.
  • Adjuvant Treatment:Following surgery for node-positive or node-negative breast cancer.
  • Ductal Carcinoma In Situ (DCIS):To reduce the risk of invasive breast cancer after surgery and radiation therapy.
  • Risk Reduction:For women at high risk of developing breast cancer.

Dosage The recommended dosage for NOLVADEX is typically 20 mg daily for five years. This regimen has been shown to significantly lower the risk of recurrence and mortality associated with breast cancer.

Mechanism of Action Tamoxifen acts as an antagonist in breast tissue but can act as an agonist in other tissues such as the uterus. This dual action allows it to inhibit tumor growth while potentially stimulating endometrial tissue, which can lead to increased risks of uterine malignancies.

Side Effects While NOLVADEX is generally well-tolerated, it carries risks of serious side effects including:

  • Uterine Malignancies:Increased incidence of endometrial adenocarcinoma and uterine sarcoma.
  • Thromboembolic Events:Higher rates of stroke, pulmonary embolism, and deep vein thrombosis compared to placebo.
  • Common Side Effects:Hot flashes, vaginal discharge, menstrual irregularities, weight loss, and mood changes.

Clinical Studies Clinical trials such as the NSABP P-1 trial have provided data on the efficacy and safety profile of NOLVADEX. The trial demonstrated that while tamoxifen reduces breast cancer incidence in high-risk women, it does not eliminate the risk entirely.

Monitoring and Considerations Healthcare providers should carefully assess the benefits versus risks when prescribing NOLVADEX. Regular monitoring for potential side effects is essential during treatment.

In summary, NOLVADEX (tamoxifen citrate) serves a critical role in managing breast cancer through its unique mechanism as a SERM while necessitating careful consideration due to its associated risks.

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